A particle-based microfluidic molecular separation integrating surface-enhanced Raman scattering sensing for purine derivatives analysis

A particle-based microfluidic molecular separation (PMMS) system was developed which integrates SERS substrate to separate complicate molecule mixture followed by in situ SERS detection. The platform consists of an automatic microfluidic control system to precisely control the sample and reagent flow. The miniaturized PMMS–SERS system enables an easy-to-use and sensitive analyte detection, which could be … Read more

Localized surface plasmon resonance (LSPR) sensor integrated automated microfluidic system for multiplex inflammatory biomarker detection

A localized surface plasmon resonance (LSPR) sensor enables continuous and dynamic inflammatory biomarker detection, we utilized  to perform label-free molecule sensing. The small LSPR sensing mechanism simplifies optical setup and can be easily integrated with a microfluidic device.  An automated microfluidic control system was developed to control reagent guiding and switching in the immunoassay with … Read more

Clinical translation of microfluidic sensor devices: focus on calibration and analytical robustness

This paper discusses approaches to facilitate the use of microfluidics by non-experts in clinical settings outside of the laboratory. The researchers demonstrate a flexible microfluidic platform that can be coupled to microfluidic biosensors and used in conjunction with clinical microdialysis. The precision and control offered by this set-up enables the use of microfluidics by non-experts … Read more

Gel Electrophoresis Temperature Regulation with the uProcess uEP01 Power Supply

Maintaining constant temperature for gel electrophoresis applications provides several key benefits over the typical method of maintaining constant power. This application note shows how to use LabSmith’s uProcess™ microfluidic automation software and the uEP01 Electrophoresis Power Module to maintain constant temperature. Download the Application Note here. Download the sample uProcess automation script here.

Zero Dead-Volume Mixing with uProcess and Hummingbird Nano Chips

This application note describes how to set up a zero dead volume mixing process using LabSmith’s uProcess syringe pumps, valves, reservoirs and software, and Hummingbird Nano “X” style or “Y” style helical mixer chips. Download the Application Note here. Download the sample uProcess automation script here.

Microfluidic ChipShop Fluidic Interface Options

This guide shows the CapTite™ microfluidic connections required to interface with various, common types of chips available from Microfluidic ChipShop. The types of chips shown below are available through LabSmith as well as through Microfluidic ChipShop.

How to Make Leak-Free, Zero Dead-Volume Microfluidic Connections

CapTite™ fluid routing components provide leak-free connectivity, even at high pressures, for fluid circuits with 360μm capillary, 1/32″ and 1/16″ tubing. This application note describes how to make reliable, tight connections using LabSmith’s CapTite™ microfluidic connectors. View the related video here.

Automated Multi-Fluid Injection Using an 8-Position Selector Valve

This application note shows you how to create a pressure-driven microfluidic injection for up to seven fluids using off-the-shelf components. LabSmith’s AV801 8-port selector valve, and LabSmith’s other uProcess valves, pumps, sensors and scripting software, make it easy assemble the microfluidic circuit and program the flows. Download the Application Note here. Download the sample uProcess … Read more

uProcess Thermal Control

The uProcess™ uTS temperature sensors, uTE thermal module, and the uProcess software make it easy to monitor and control your micro-process application. This note describes how to use the uProcess thermal devices, with examples and tips for getting the best results from your sensors and controllers, and detailed temperature regulation examples. For these examples the … Read more