This application note describes how to set up a zero dead volume mixing process using LabSmith’s uProcess syringe pumps, valves, reservoirs and software, and Hummingbird Nano “X” style or “Y” style helical mixer chips. Download the Application Note here. Download the sample uProcess automation script here.
The uProcess™ uTS temperature sensors, uTE thermal module, and the uProcess software make it easy to monitor and control your micro-process application. This note describes how to use the uProcess thermal devices, with examples and tips for getting the best results from your sensors and controllers, and detailed temperature regulation examples. For these examples the … Read more
This application note describes how to set up a microfluidic pressure-driven flow controller using uProcess syringe pumps, valves, and pressure sensors. Download the Application Note here. Download sample uProcess automation scripts here.
Microfluidic devices, with their potential for portability and rapid analysis times, can bring cost-effective flexibility to modern analytical chemistry applications. However, the design and fabrication of microchips can involve trade-offs between cost, flexibility of configuration, and ideal surface properties or performance. To circumvent these drawbacks, we have developed a hybrid platform consisting of simple microfabricated … Read more
The manipulation of biological samples for diagnostic purposes requires reproducibility and simplicity to be useful in practice. As microfluidic devices transition towards use in medical diagnostics, traditional handheld syringe pumps can be too bulky and laborious for medical procedures that require quick turnaround times. Here, we discuss the evaluation of a portable breadboard platform that … Read more
Hydrodynamic focusing capitalizes on the inherent advantages of the flow physics of a microfluidic system to overcome functional challenges encountered in microfluidic conditions such as mixing and the delivery of particles such as cells for counting. Hydrodynamic focusing requires reproducible flow rates, valving, and automated control of pumps and valves to direct the processes on … Read more
A ubiquitous problem in analytical chemistry is the push to increase signal-to-noise (S/N) and to lower the limits of detection (LOD) for many sample separation methods. Low S/N is typically due to the inherent low concentration of the sample in the system and the band-broadening of the sample in dead volumes of the analytical system. … Read more
The microfluidic chip platform offers an advantage for electrokinetic chemical separations by eliminating the dead volume normally encountered with tubing connections. In order to capitalize on this advantage, sample injections must be performed on chip. The gated injection loads a variable injection volume by controlling velocity and injection time. The gated injection controls plug size … Read more
LabSmith’s LabPackage makes it easy to build, control and monitor simple and complex microfluidic manipulations. This experiment was designed to help you train your laboratory team and test competency on performing a pinched electrokinetic microfluidic injection techniques. It can also be used to test equipment, chips and reagents to ensure that they are working properly. … Read more
Sample preparation is a bottleneck for protein, cell and nucleic acid analysis, regardless of the analytical technique used. An important, and tedious, preparation step is selective concentration of the target of interest, particularly when target abundance is low. One approach is insulator-based dielectrophoresis, or iDEP, in which insulators, often etched in glass or stamped in … Read more