Lab-on-a-Chip Application: Microfab-less Microfluidics for a Portable Hybrid Microchip-Capillary Electrophoresis Device
Microfluidic devices, with their potential for portability and rapid analysis times, can bring cost-effective flexibility to modern analytical chemistry applications. However, the design and fabrication of microchips can involve trade-offs between cost, flexibility of configuration, and ideal surface properties or performance. To circumvent these drawbacks, we have developed a hybrid platform consisting of simple microfabricated reservoirs connected to standard capillary tubing for electrophoretic separation and in-channel detection. The connections for this hybrid device are assembled using a reusable, conventionally machined CapTite™ Ultem® cross interconnect and CapTite™ PEEK™ capillary fittings. The Ultem® central interconnect, s silicone reservoirs, and conductivity detector can all be mounted to a portable breadboard for stability. The use of standard capillary tubing with a conventionally machined cross supports versatile system configurations and simultaneously eliminates the cost in money and time that is associated with customized microfabrication.