Zero Dead-Volume Mixing with uProcess and Hummingbird Nano Chips

This application note describes how to set up a zero dead volume mixing process using LabSmith’s uProcess syringe pumps, valves, reservoirs and software, and Hummingbird Nano “X” style or “Y” style helical mixer chips. Download the Application Note here. Download the sample uProcess automation script here.

Microfluidic ChipShop Fluidic Interface Options

This guide shows the CapTite™ microfluidic connections required to interface with various, common types of chips available from Microfluidic ChipShop. The types of chips shown below are available through LabSmith as well as through Microfluidic ChipShop.

How to Make Leak-Free, Zero Dead-Volume Microfluidic Connections

CapTite™ fluid routing components provide leak-free connectivity, even at high pressures, for fluid circuits with 360μm capillary, 1/32″ and 1/16″ tubing. This application note describes how to make reliable, tight connections using LabSmith’s CapTite™ microfluidic connectors. View the related video here.

Degassing a Microfluidic System

Dissolved gas and trapped air bubbles in a microfluidic system can affect repeatability and stability. Degassing a fluid system is easy using a LabSmith Breadboard Reservoir or Chip Reservoir.

Step-by-Step Simple Flow Setup and uProcess Automation

For over a decade, LabSmith has been making microfluidic tools used in top research labs around the world, and we are now making these tools available for high-school and undergraduate programs. Our Microfluidics Education Toolkits will include a modular array of microfluidic control instruments and sensors, interactive software, and curriculum packages to help educators teach … Read more

Microfab-less microfluidic capillary electrophoresis devices

Thiago P. Segato, a Samir A. Bhakta, Matthew T. Gordon, Emanuel Carrilho, Peter A. Willis, Hong Jiaod and Carlos D. Garcia,  Anal. Methods, 2013, 5, 1652 (One of the Top 25 Most Read Analytical Methods Articles of 2013). ABSTRACT Compared to conventional benchtop instruments, microfluidic devices possess advantageous characteristics including great portability potential, reduced analysis … Read more

Lab-on-a-Chip Application: Microfab-less Microfluidics for a Portable Hybrid Microchip-Capillary Electrophoresis Device

Microfluidic devices, with their potential for portability and rapid analysis times, can bring cost-effective flexibility to modern analytical chemistry applications. However, the design and fabrication of microchips can involve trade-offs between cost, flexibility of configuration, and ideal surface properties or performance. To circumvent these drawbacks, we have developed a hybrid platform consisting of simple microfabricated … Read more

Applying Voltage to a Channel in a Microfluidic Chip

Platinum wire electrodes are commonly used to apply voltage to a fluidic channel. Although the approach is relatively simple, proper preparation of the electrode is very important to prevent field concentrations in the channels. Field concentrations can cause a multitude of problems, including bubble formation, cell lysing, localized heating, chemical reactions, and clogging of channels.

Lab-on-a-Chip uProcess™ Application: Continuous Dispensing

Particularly in biological experiments, it is necessary to deliver fluid at flow rates of ≤ 1μl/min over experiment times of hours to days.  As a result, a relatively large total volume is dispensed to the experiment, sometimes as much as 1-10 ml. In lab-on-a-chip experiments, a small overall experimental platform is often desired. This creates the challenge of … Read more

Hydrodynamic Focusing using Integrated Modular Pumps, Valves, Connectors & Imaging

Hydrodynamic focusing capitalizes on the inherent advantages of the flow physics of a microfluidic system to overcome functional challenges encountered in microfluidic conditions such as mixing and the delivery of particles such as cells for counting. Hydrodynamic focusing requires reproducible flow rates, valving, and automated control of pumps and valves to direct the processes on … Read more